Home Services Products Resources About Us News Contact Us
PTH 1-84 Calcemia Panel

 

The Classification of Hypo/Hyper Calcemia

 

Hypo/hyper calcemia can be caused by a wide variety of diseases. These diseases can be classified into those that are PTH dependent or PTH independent, thus making the measurement of PTH vital in the classification of the hypo/hyper calcemia.

 table

The parathyroid hormone (PTH) consists of an 84 amino acid sequence. PTH has a very short half-life and quickly degrades to fragments. In patients with renal insufficiency, these fragments can accumulate and interfere with the measurement of PTH. Over the years, assays have evolved to remove this interference with intact-PTH (iPTH) being routinely offered; however it was later learned iPTH cross-reacts with the 1-34 fragment. Because of this, a new more effective marker was needed; enter PTH 1-84.

PTH 1-84 is the latest generation of PTH assays that measures the complete 1-84 sequence and therefore eliminates all cross-reactivity to PTH fragments. This assay is now available from VDI for both cats and dogs.

PTH 1-84 is used exclusively in the  VDI Calcemia Panel, a 3-test panel that provides fast classification of canine or feline hypo/hyper calcemia.

 

Example Cases using the VDI Calcemia Panel

 

Primary Hyperparathyroidism due to Benign Tumor

The Calcemia Panel contains two graphics that plot the relationship between PTH vs. calcium and PTH vs. vitamin D. In a normal healthy dog or cat, the patient should plot within the green shaded area.

 chart

This patient's hypercalcemia is PTH dependent (too much PTH) caused by a benign tumor of the parathyroid gland (primary hyperparathyroidism). The patient is also mildly vitamin D insufficient.

 

Hypercalcemia of Malignancy

 graph

This patient's hypercalcemia is PTH independent caused by a malignant tumor (hypercalcemia of malignancy). The patient has adequate vitamin D stores.

Hypoparathyroidism Secondary to Vitamin D Deficiency

 graph

This patient's hypocalcemia is PTH independent caused by a severe vitamin D deficiency (secondary hypoparathyroidism).

 

Primary Hyperparathyroidism

 graph

This patient's hypocalcemia is PTH dependent (too little PTH) caused by chemotherapeutic damage to the parathyroid gland (primary hypoparathyroidism). The patient is mildly vitamin D insufficient.

 

 

INCASE report

 

 

 

The Right Tests for the Right DecisionSM                                                                                                                   


 

 

 

 

Test ORDERING / Specimen HANDLING
Our Partners
 
the VDI Review
...the newsletter designed to effectively share our progress in the fields of Cancer, Infection, Inflammation,... more
NEW: Vitamin D Test Kit
Simpler & More Cost-effective Testing VDI is pleased to introduce a new Vitamin D Test Kit that greatly simplifies... more
Cancer
Two individual blood tests for the detection and management of canine & feline cancer & one for wellness... more
Home Products Services Resources About Us News Contact Us
© 2014 Veterinary Diagnostics Institute ™ All Rights Reserved