Gastrointestinal disorders are caused by multiple factors. After common baseline tests rule out other sources, we are often left with IBD or intestinal lymphoma as the most likely cause of the illness.
Intestinal wall thickening, common to both IBD and intestinal tumors, is confirmed using ultrasound. Although an important tool on the path to diagnosis, ultrasonography is not solely effective in distinguishing lymphoma from IBD.
Definitive diagnosis of lymphoma or IBD is obtained through histopathological evaluation of intestinal biopsies. Full thickness biopsy obtained surgically offers a more thorough evaluation of all tissue compartments compared to endoscopic biopsy and is the preferred means of diagnosing intestinal lymphoma.
Financial constraints and/or concerns over the invasiveness of biopsy force many cat owners to seek alternatives. For those willing pet owners, the decision to pursue biopsy is made easier when greater evidence points to lymphoma as being the more likely cause of the illness. That is where a blood test that helps discriminate between IBD and lymphoma plays a major role in the diagnostic pathway.
Dual Biomarker Test Design TKFELINE CANCER PANEL combines the information obtained from two independent measures of system irregularity; abnormal cell division and systemic inflammatory activity. Thymidine kinase (TK) is a measure of dysregulated cellular proliferation. Haptoglobin (Hpt) is elevated in the presence of systemic inflammatory disease.
Neoplasia & Inflammation
There has been a long standing and studied relationship between cancer and inflammation. Research shows that inflammation plays an essential role at each stage of the disease (initiation and proliferation), and has demonstrated that the effectiveness of tumor development correlates directly with the degree of the inflammatory reactions.
The Neoplasia Index (NI) is a dual-biomarker algorithm that combines the dysregulated proliferation marker TK and the systemic inflammatory marker CRP. These two independent variables - thymidine kinase & CRP - combines two distinct hallmarks of neoplasia; rapid dysregulated cell division & systemic inflammation. The algorithm developed to integrate the dual biomarkers, produces the resultant Neoplasia Index.
161 cats of various breeds, ages and both genders were enrolled in a multi-institutional study including 50 with disease (LSA n=29, IBD n=21) and 111 apparently healthy control cats.
Findings: Progressively elevated neoplasia index (NI) values were observed with the IBD and LSA groups compared with the control group. NI population separation was observed between all three groups.
The Right Tests for the Right DecisionSM