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Canine Cancer Blood Test

 

TKcanine cancer panel
For the detection and therapeutic management of cancer in dogs with suspected or confirmed cancer

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Clinical Background

Cancer is a common disease affecting dogs of all age, size & breed. The signs of cancer are often nondescript and can mimic many other types of diseases making the diagnosis of cancer challenging, often invasive and expensive. Once diagnosed, veterinarians have had few tools available to effectively monitor the course of treatment or disease progression.

TKCANINE CANCER PANEL has been clinically proven effective on a wide variety of tumor types. When a suspicious mass is identified, or the dog presents with other indicators common with cancer, the cancer panel is used to detect the presence of neoplastic disease.

 Tumor Class

TKCANINE CANCER PANEL combines the information obtained from two independent measures of cellular irregularity; abnormal cell division and systemic inflammation. Thymidine kinase type 1 (TK1) is a measure of dysregulated cellular proliferation - a hallmark of cancer. C-reactive protein (CRP) is elevated in the presence of systemic inflammatory disease. United through the Neoplasia Index (NI), the test panel provides objective evaluation for disease.

The panel is useful for monitoring treatment and disease progression. For patients undergoing therapy, results from the cancer panel can quickly indicate that the patient is responding to the treatment protocol, as indicated when both TK1 and CRP decline from the initial pretreatment assessment. With resistance to therapy, TK1 and CRP will be unresponsive and remain elevated. Upon disease recurrence, TK1 and CRP will elevate from baseline. Retesting intervals are recommended at 4-8 week intervals.

Methodology
 Chemiluminescent and Sandwich Immunoassay 
Units (Range)  TK1 U/L (0.5-100)  CRP mg/L (0.5-50)  NI index (0-10)
Sample Requirements  
Serum≥1mL; SST tube / separate & freeze within 45 min
Interferences  Gross hemolysis / Gross lipemia
Stability  Room temp: 1 hour / 4 °C: 4 hours / -20 °C: 30 days

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TK canine header


 

Dual Biomarker Test Design

TKCANINE CANCER PANEL combines the information obtained from two independent measures of system irregularity; abnormal cell division and systemic inflammatory activity. Thymidine kinase (TK) is a measure of dysregulated cellular proliferation. C-reactive protein (CRP) is elevated in the presence of systemic inflammatory disease.
 
 Dual-marker 
 Neoplasia & Inflammation

There has been a long standing and studied relationship between cancer and inflammation.  Research shows that inflammation plays an essential role at each stage of the disease (initiation and proliferation), and has demonstrated that the effectiveness of tumor development correlates directly with the degree of the inflammatory reactions.

 

Cancer Detection & Monitoring

Detection

TKCANINE CANCER PANEL has been clinically proven effective on a wide variety of tumor types. When a suspicious mass is identified, or the dog presents with other indicators common with cancer, the cancer panel is used to detect the presence of neoplastic disease.

 Tumor Class

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Therapeutic Monitoring

For patients undergoing chemotherapy, results from the cancer panel can quickly indicate that the patient is responding to the treatment protocol, as indicated when the values decline from the initial pretreatment assessment.

monitoring chart

 

 

TKCANINE CANCER PANEL is used following surgical procedures to monitor neoplastic disease status. Following definitive surgery, the test is used to assess the completeness of excision.

When the nature of the cancer or patient status renders treatment impractical, the cancer panel is used to monitor disease progression. In certain cases, the disease may remain in a stable state where the tumor advances slowly even in the absence of treatment. With other cases, untreated or minimally treated cancer will advance rapidly. 

 

 

 

 

 

INCASE report

 

 

 

 

                                                                                                               

 

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