Chronic inflammation is both associated with, and the root-cause of disease. Left unchecked, chronic inflammation can lead to disease advancement and even death.
HPTEQUINE is a blood test that detects systemic inflammation in response to infection, tissue damage, neoplasia, and trauma. The test is used to confirm the presence of inflammatory disease, detect hidden disorders, monitor the effectiveness of treatment, and assure complication-free recovery.
HPT & The Inflammatory Process
The acute phase response is a complex, systemic early-defense system activated by infection, inflammation, trauma and tissue damage or necrosis. Although nonspecific, it serves as a core of the innate immune response. It involves physical and molecular barriers and responses that serve to prevent infection, clear potential pathogens, initiate inflammatory processes, and contribute to resolution and the healing process.
- Surgical trauma
- Tissue necrosis
Haptoglobin (HPT), serves as a moderate acute phase protein in horses. Levels of circulating Hpt elevate rapidly upon initiation of an inflammatory event. HPT serves as an index of both the severity and duration of the inflammatory stimulation. Once the trigger of the inflammation is resolved, HPT levels drop back to normal levels.
Damage Associated with Chronic Inflammation
"Acute Inflammation Defends, Chronic Inflammation Kills"
Acute (short-term) inflammation is a vital life-sustaining function. The complex cascade of events that occurs is needed to initiate a defense against invading bacteria and to repair tissue damage that occurs from trauma, infection, and disease.
While acute inflammation is normally tightly controlled and part of the healing process, chronic (long-term) inflammation is associated with a number of diseases.
- Health Screen - detect subclinical disease
- Monitor disease progression & response to treatment
There is a direct correlation between HPT concentration and the severity and duration of the inflammation. Hence if therapy is successful, HPT will drop quickly. This is useful to monitor the treatment of infections and diseases that induce an inflammatory response. HPT concentrations will react to changing states within the horse within hours making it a very useful measurement for “real-time” monitoring.
The Right Tests for the Right DecisionSM