In order for a wellness screen to be effective, it must be able to detect a full spectrum of early stage serious occult disease, for better outcomes and lower overall treatment cost. Many tests currently being used for screening, leave out one important disease- cancer. Given it affects 1 out of 3 dogs, and 50% over the age of 10, a truly effective screening test should be able to detect it. INCaSe® does just that- it casts a wide net covering many diseases, including cancer.
Dual Biomarker Test DesignINCaSe® combines the information obtained from two independent measures of system irregularity; abnormal cell division and systemic inflammatory activity. Thymidine kinase (TK) is a measure of dysregulated cellular proliferation. C-reactive protein (CRP) is elevated in the presence of systemic inflammatory disease.
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Hidden Disease in the 'Apparently Healthy' Dog
A major clinical study conducted with the University of Missouri and Tufts University was published in Veterinary and Comparative Oncology . The initial intent of the study was to examine how TK and CRP could be used to detect cancer in apparently healthy dogs, but was expanded to investigate overall health. In a large study group of 360 dogs followed for up to one year, incidence of cancer and serious disease were followed:
Cancer Risk Assessment Score (CRA)
Identify dogs at risk for cancer
C-Reactive Protein (CRP) Evaluation
Identify hidden disease through the presence of inflammatory response
CRP and Serious Disease
CRP is very sensitive to a wide range of inflammatory disease such as heart disease, kidney disease, and autoimmune disorders. Within the study, if you only looked at death as an endpoint of serious disease, those with increasingly elevated CRP had a higher mortality rate, up to one fourth, compared to only 3% with low CRP.
The Right Tests for the Right DecisionSM