Advanced GI Panel

What’s wrong with this GI cat or dog? Differentiate GI diseases using a single blood panel for IBD, LSA, Pancreatitis, PLE and Vitamin Deficiencies.

A Simple Blood Panel for a Complex Problem

Patients presenting with gastrointestinal signs can be a challenging workup as the disease pathology can be multi-factorial.  Diseases such as IBD, pancreatitis, PLE, LSA, SIBO may exist concurrently so no ONE TEST can do it all. 

VDI Lab has assembled and integrated a unique array of tests to help identify what the exact problem is using a single blood panel.  Being a simple blood draw means it’s NON-INVASIVE, COST-EFFECTIVE, and useful for initial workup and therapeutic monitoring.

12 Parameters – One Panel

Advanced GI Panel diagram
CRP (dog) or HPT (cat)TK1Neoplasia Index­®
Vitamin DVitamin B12Folate
Magnesium Total ProteinAlbumin
GlobulinA/G RatiocPL/fPL (SNAP)


The Advanced GI Panel aims to answer your real question: What is wrong with my GI patient? By integrating multiple tests (often ran through separate labs) with VDI’s unique GI Lymphoma Panel, VDI is able to provide diagnostic insight into:

  • Lymphoma vs IBD vs food-related
  • Pancreatitis
  • Protein Losing Enteropathy
  • Nutritional deficiencies
  • Malabsorption & SIBO

Context Aware

VDI integrates case context, medications, and signalment into the diagnostic AI to improve results interpretation, adding confidence to the diagnoses. Let us take some of the work off your shoulders and simplify the complex interpretations.

Clinical Review

Every Advanced GI Panel undergoes clinical review of any relevant information provided on the requisition form to ensure all interpretations are context-sensitive and patient-centric.


Actionable items start with patient-specific test interpretation and recommendations that are unique to the individual. For all essential vitamin tests, VDI provides individualized dosing recommendations to correct deficiencies.

Lab Report Samples

View some samples of actual lab reports by clicking on the images below.

GI Lymphoma Panel – included with the Advanced GI Panel

  • Application specific Neoplasia Index® resulting in better Sensitivity/Specificity, especially with Small Cell LSA.
  • Indicates if LSA is more likely: Large Cell, Small Cell, or Thoracic.
  • B12/Folate report provides additional information on status of the GI tract.

Scroll down to learn more on the Neoplasia Index .


The Advanced GI Panel utilizes disease activity markers that respond to changes in disease state. Use of anti-inflammatory medications like NSAIDS/Corticosteroids and Chemotherapy may impact results, however this does not eliminate the utility of the panel.

Contact VDI for further information regarding the impact of medication on results. All VDI Cancer & GI Panels can be used to monitor the effectiveness of therapy and disease progression.

The Neoplasia Index: NI GILSA

The Neoplasia Index is the primary test value used in the diagnostic workup of the GI patient

Neoplasia Index (NI GILSA)

The Neoplasia Index (NI) is meant for the diagnostic rule-in of cancer. Developed as a general cancer marker used in the VDI Cancer Panel, the NI is the primary value used for differential diagnosis of cancer. The NI is unit-less index from 0-10 with 0 being a perfectly normal animal, to 10 being a perfect score for cancer.

Combining independent markers into a unified algorithm improves performance. The base Neoplasia Index incorporates Thymidine Kinase Type 1 and C-Reactive Protein for dogs or Haptoglobin for cats as a general cancer rule-in.

The expanded NI GILSA, is a specific application for GI lymphoma. It incorporates TK1, CRP/HPT, B12, and Age. As you can see below, the NI GILSA, separates groups remarkably well, and the NI GILSA compensates for B12 deficiency and is able to differentiate small cell vs large cell. 

Box and Whiskers plot of Neoplasia Index values vs Clinical status of the cat.  Test sensitivity and specificity is also listed.

Profiles in the untreated patient

In the untreated cat, the levels of TK1, CRP/HPT, and B12 can indicate different disease states commonly associated with that specific marker profile. Below are some examples of the profiles in the GI cat that are indicated when the resulting markers are increased, decreased, or normal.

Chart with the analyte profiles (TK1, HPT, B12) that correspond with various disease states in GI cats.

Lab Report Samples (GI Lymphoma Panel only)

View some samples of actual lab reports by clicking on the images below.