017 – Inflammation + B12

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Acute Phase Proteins (APP) are the best indicators of inflammation in the body. The major APPs (CRP in dogs, HPT in cats) are made when an inflammatory stimulus is present, and disappear when it’s resolved. Quick to appear and disappear, CRP & HPT should be normal in the healthy animal.  When present, source of inflammation should be identified and resolved if possible before it becomes chronic.  Chronic inflammation leads to the development of serious diseases including cancer.  Detect occult disease in the otherwise healthy looking animal using C-reactive Protein (CRP) in dogs, or Haptoglobin (HPT) in cats.

Vitamin B12 is an essential vitamin that plays a role in DNA synthesis.  As an essential vitamin it’s only obtained through the pet’s diet.  Low B12 values can indicate diet deficiency or the presence of disease that inhibits absorption. VDI provides patient-specific dosing guidelines to get patients to normal.

Clinical Applications:

CRP and HPT are also useful in pre-operative test panels and therapeutic monitoring.


Dogs & Cats on steroids or NSAIDs will have suppressed CRP or HPT, unless the medication is no longer having an effect on the disease process. Whenever possible, collect sample before the administration of anti-inflammatory medications.

Additional information


Canine, Feline

Patient Status

Acutely Ill, Apparently Healthy


C-Reactive Protein (CRP), Haptoglobin (HPT), Vitamin B12 (B12)

Specimen Type

Serum (Frozen or Dry)

Dry Serum Volume

1 Well


Recommended: 8hr