234 – GI Lymphoma Panel + VitD

Background:

The GI Lymphoma Panel is for the diagnosis and monitoring of cancer in the dog or cat with GI signs, suspected of Chronic Enteropathy.  Unifying a blood marker of abnormal cell proliferation, Thymidine Kinase Type 1 (TK1), inflammatory marker CRP or HPT (species dependent), and B12/Folate into the Neoplasia Index­, the Lymphoma Panel is a Rule-in for GI Lymphoma.   VDI provides context-sensitive results interpretation and clinical review on all Cancer Panels.  B12 and Folate, when evaluated together, can provide insight into the location of GI distress.   Learn More.

Vitamin B12 is an essential vitamin that plays a role in DNA synthesis.  B12 deficiency can cause errors in that process which may cause TK1 to elevate.  Vitamin D is the most important hormone in the body and sufficient levels are anti-proliferative, pro-differentiating, and anti-inflammatory: all involved in cancer pathogenesis.  VDI provides patient-specific dosing guidelines to get patients to sufficiency.  VDI provides patient-specific dosing guidelines for both B12 and Vitamin D.

Clinical Applications:

1. Suspected GI Lymphoma
   • GI Cat or Dog
   • ADR (Ain’t Doing Right)
   • Suspicious signs/imaging
2. Confirmed Cancer
   • Monitor Therapy Efficacy
   • Monitor disease progression
   • Determine remission & identify early signs of relapse
   • Identify metastatic disease

Recommendations:

The GI Lymphoma Panel + VitD should be performed prior to administration of steroids, chemo, NSAIDs or other therapy whenever possible.  VDI can interpret results around the presence of therapy, but please be sure to indicate on the Test Requisition Form any medications at the time of draw.

Repeat testing (monitoring) is suggested at varying time windows depending on the patient status, diagnosis, and application.  Contact VDI for consultation on any case to determine the best repeat test window.