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“Hypercalcemia of Malignancy” may not be due to malignancy

The term “hypercalcemia of malignancy” is routinely used when calcium is elevated and PTH is below normal, and for good reason— this situation is often a result of malignant neoplasia, particularly lymphoma, anal sac adenocarcinoma, or multiple myeloma.  However, many other diseases can fall into this category such as granulomatous disease, hyperthyroidism, vitamin D intoxication, and Addison’s […] Read more »

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Vitamin D & Inflammatory Bowel Disease

Inflammatory bowel disease (IBD), an auto-immune disorder, is characterized by chronic intestinal inflammation and can advance to protein-losing enteropathy (PLE), an often fatal disease.  Dogs with IBD are often low in vitamin D stores (25VitD) due to inappetence and/or impaired absorption. Studies (1,2) have found a correlation between the level of 25VitD and the canine […] Read more »

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Atopic Dermatitis and Vitamin D

Published in Veterinary Record (1) is an interventional study on the effects of vitamin D supplementation on dogs with atopic dermatitis.  Conclusion: Oral vitamin D decreased both pruritus and also acute and chronic skin lesions in dogs with AD.  The improvement in the dogs with pruritus was significantly correlated with an increase in serum 25-OH-D3 […] Read more »

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Vitamin D Status Affects Heart Disease

Research in both human and veterinary medicine shows vitamin D to be an independent risk factor for adverse cardiac events.  Two recent studies looked at the association between Vitamin D levels and Chronic Valvular Heart Disease (CVHD). Kraus, et. al., found that in dogs, low stores of 25(OH)D were associated with CVHD, as well as a 2.6 times greater hazard of having a […] Read more »

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Biomarker Concentration and Survival Time in Dogs with Protein-Losing Enteropathy

Protein-losing enteropathy (PLE), a syndrome of excessive loss of protein into the lumen of the GI tract, can be associated with a wide range of serious inflammatory diseases such as neoplasia and IBD as well as less severe disorders like food responsive diarrhea (FRD).  Left untreated, PLE is often fatal. In the January issue of JAVMA, […] Read more »

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Response to treatment using CRP in dogs with IMPA

Immune-mediated polyarthropathy (IMPA) is a common cause of chronic relapsing fever in dogs.  It is associated with significant pain, lameness, or with a stiff/stilted gait.  The diagnosis and monitoring of this disease requires serial synovial fluid analyses. Recently published in the Journal of Veterinary Internal Medicine , Foster, et. al, found that CRP is useful as a […] Read more »