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Vitamin D Status Affects Heart Disease

Research in both human and veterinary medicine shows vitamin D to be an independent risk factor for adverse cardiac events.  Two recent studies looked at the association between Vitamin D levels and Chronic Valvular Heart Disease (CVHD).

Kraus, et. al., found that in dogs, low stores of 25(OH)D were associated with CVHD, as well as a 2.6 times greater hazard of having a cardiovascular event. Asymptomatic dogs were not part of this cohort.

More recently, Osuga,, compared Vitamin D status on patients with B1 asymptomatic CVHD to those with B2 and C/D. 

Results show a significant drop in Vitamin D status as CVHD worsens and may indicate an association between Vitamin D status and cardiac remodeling.  While the mechanism of action is not entirely clear, it is believed endothelial dysfunction, secondary to Vitamin D insufficiency, plays a major role for the greater hazard risk.