Cobalamin (B12) and 25-hydroxy-vitamin D (25D) are dietary derived in both cats and dogs. Studies have shown 25D insufficiency to be a major problem in both species and worsen with age (1,2). B12 malabsorption is strongly associated with both chronic enteropathies (IBD) and exocrine pancreatic insufficiency (EPI) (3,4). But is there a relationship between the two? […] Read more »
It is common practice to utilize the term “B12/folate” as if it were one, which makes sense when looking at their biological pathways. Both are required for the methylation of homocysteine to methionine. However when discussing sources and deficiencies, they are very different. Whereas the opportunities for cobalamin deficiency are numerous, folate deficiencies are far less common. […] Read more »
Cobalamin (B12) deficiency is frequently encountered in dogs and cats with chronic enteropathies (CE) and exocrine pancreatic insufficiency (EPI). B12 metabolism follows a complex array of carriers to be effectively absorbed which can be negatively impacted by intestinal inflammation and dysbiosis. In human patients oral supplementation is often utilized, while repeated parenteral injections is often […] Read more »
Cobalamin (B12) metabolism requires many complex pathways, in which a breakdown of any could lead to B12 deficiency. In a system that has many points for breakdown, having adequate B12 begins with a quality food source. Like vitamin D, animal protein is the primary source of B12 – a concern with vegan diets. Provided there is […] Read more »
It is well documented that cats and dogs with chronic enteropathies (CE), intestinal lymphoma, or exocrine pancreatic insufficiency are often cobalamin (B12) deficient (1,2). Problems with intrinsic factor binding to ileal receptors in the diseased tissue leads to B12 deficiency. Current supplementation protocol calls for repeated parenteral injections of hydroxycobalamin over 6 weeks bypassing the diseased tissue. […] Read more »
